Comparison of the in vitro activity of linezolid, tedizolid, sutezolid, and delpazolid against rapidly growing mycobacteria isolated in Beijing, China

BackgroundThe natural resistance of rapidly growing mycobacteria (RGM) to multiple antibiotics renders the treatment infections caused less successful. The objective this study was evaluate in vitro susceptibilities four oxazolidinones against different RGM species.MethodsThe microplate alamarBlue assay performed identify minimum inhibitory concentrations (MICs) – delpazolid, sutezolid, tedizolid, and linezolid for 32 reference strains 115 clinical species. MIC breakpoint concentration defined as 16 μg/ml linezolid. Next, gene fragments associated with oxazolidinone were amplified sequenced, mutations contrast sequences strains.ResultsTedizolid showed strongest activity Mycobacterium abscessus isolates. Delpazolid exhibited better antimicrobial fortuitum isolates when compared linezolid, 4-fold lower values. protein alignment structure-based analysis that there might be no correlation between rplC, rplD, 23S rRNA genes tested RGM.ConclusionsTedizolid had M. vitro, while delpazolid presented best fortuitum. This provides important insights into potential application treat infections.